Manchester United begin life in the top flight against their neighbours.
United only launched their women’s team 15 months ago but many are already tipping them to break into the WSL’s top four.
“I think last year was complete stress because I was having to recruit 21 players in a space of four weeks as well as get my staff in place,” said United boss Casey Stoney.
“Now I feel I can just concentrate on the grass and developing players, making sure everyone knows their roles and responsibilities, and making sure we’ve got the staff structure around them to support them.
“It’s obviously a different pressure for me now going into the top league.”
Manchester City finished as runners-up behind Arsenal in the WSL last season.
But captain Steph Houghton is determined to go one step further this term.
“The league is the big one and we want to get our hands back on that trophy and I feel the pre-season we’ve had and the players we have brought in give us a great chance of achieving our goals,” Houghton said.
“It’s OK to say it, now we have to show we are one of the best teams in the country.”
The match is being held at City’s Premier League ground, the Etihad Stadium.
What time does Man City vs Man Utd kick-off?
The WSL match gets underway at 3pm BST at the Etihad Stadium.
What TV channel is Man City vs Man Utd on?
Fans can watch the game live on BT Sport 1 throughout the UK.
Existing customers can stream the action via the BT Sport app and on the company’s website.
Can I live stream Man City vs Man Utd for free?
Yes, fans will be able to stream the Manchester derby for free via the FA Player.
This can be done through the website or by downloading the app.