Over in the US, the interview will air on CBS on Sunday 7 March at 8pm Eastern Time, but what about the UK?
Well, here we can reportedly catch the interview at 9pm on Monday March 8 over on ITV, after the BBC dropped out of the race, the Daily Mail reports.
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So far, we’ve seen snippets of what to expect, with CBS releasing teaser trailers ahead of the big interview.
In the clips, we see that Meghan, Harry and Oprah are sitting outdoors in a stunning setting surrounded by flowers and trees in a very secluded spot.
The trio sit on wicker chairs on a huge rattan rug with a wooden table in the middle, and huge stone columns have vines weaving around them.
The private courtyard looks like just the spot to have a quiet conversation, and it turns out it’s the garden in the home of CBS This Morning host Gayle King.
Gayle’s gorgeous Californian mansion is the perfect place to find picturesque views, and while there’s little information about Gayle’s property she did share a peek inside recently.
The star posed inside her home and it looks like a very airy and bright abode, with statement artwork and big vases of flowers positioned throughout.
Gayle has opted for fun lettuce green furniture inside her home and the floors are wooden.
The star also shared a look at her stunning home during a video call, and fans can see just how expansive it is, with patterned wallpaper, portraits in gilded frames and large doors.
It’s no surprise Gayle has hosted the famous trio at her home for the big interview, what with Gayle and Oprah being best friends of years.
Discussing the interview, Gayle said on CBS’ This Morning: “They taped at a friend’s home. People said it was at Oprah’s house or Harry and Meghan’s, [but] it was at a friend’s home.
“She believes it’s the best she’s ever done and she said it wasn’t just her though, it was because the conversation apparently was so candid with all three of them.
“They all look comfortable sitting talking to one another.”
In the teaser for the chat, Prince Harry emotionally reveals his “biggest concern was history repeating itself,” referencing the tragic 1997 death of his mother Princess Diana.
It’s believed the couple will also chat about Meghan, who stuns in Giorgio Armani in the chat, “stepping into life as a royal, marriage, motherhood,” according to CBS.
The couple will then discuss their move to the US and future plans.
Talk show host Oprah can be heard saying in the trailer: “I just want to be clear to everybody there is no subject that is off-limits.”
After it was announced that Harry and Meghan had made the decision to permanently step down as working members of the Royal family last month, he revealed in the clip that he “can’t begin to imagine” what Diana was faced to go through alone.
“For me, I’m just really relieved and happy to be sitting here, talking to you with my wife by my side,” he continues to tell the chat show legend.