Mohamed Salah, Raheem Sterling and Harry Kane owners all reaped the rewards last weekend with goals, assists and bonus points galore.
Fixtures look slightly trickier this week with Manchester City facing Tottenham while Liverpool travel to Southampton for their first away game of the season.
Captain pick will be crucial with points potentially at a premium for the big names.
And Express Sport has picked some stars who you should consider handing the armband to.
Fantasy Premier League captains – GW2
Pierre-Emerick Aubameyang (Arsenal) vs Burnley (H)
Aubameyang got his tally up and running scoring the only goal of the game as Arsenal beat Newcastle last weekend.
A home tie against Burnley should provide more opportunities for the Gabonese striker to rack up those points.
Raheem Sterling (Man City) vs Tottenham (H)
It may be wise to steer clear of this match, but if you’re desperate, Sterling has to be the way to go.
A hat-trick on the opening weekend against West Ham, he’s likely to be a main threat again.
Anthony Martial (Man Utd) vs Wolves (A)
Martial has already seen his price rise by £0.1m this season after a goal in United’s opening win over Chelsea.
The Frenchman played through the middle in that game and could be a key threat against Wolves.
Mohamed Salah (Liverpool) vs Southampton (A)
Salah should always be an option to give the armband to, especially after a fine first performance of the season.
The Egyptian managed a goal and assist against Norwich last weekend, while also picking up two bonus points.
Teemu Pukki (Norwich) vs Newcastle (H)
A rogue call perhaps, but Pukki scored against Liverpool last weekend and could have more joy against Newcastle.
A cheap choice at just £6.5million, bringing the Finn in could free up some vital cash for later in the season.
TOP CHOICE: Sadio Mane (Liverpool) vs Southampton (A)
Sadio Mane was on the bench for the win over Norwich but repaid Jurgen Klopp’s faith as he scored twice having started the UEFA Super Cup win over Chelsea.
Facing his former team this weekend, Klopp is likely to give him another start.
Classified as a midfielder, Mane regularly earns double figure points so give him the armband if you can.