Halting that run against City – who have won 10 straight games – was a tough enough ask without factoring in the loss of Arteta.
Arteta previously contracted Covid back in March 2020 just before the Premier League season was halted.
One other absentee for Arsenal’s clash with City is Pierre-Emerick Aubameyang.
The Gunners skipper hasn’t featured for the club since he was punished for a disciplinary breach.
Aubameyang, who has been snubbed for the past five matches, has been given the green light to head to Dubai to link up with Gabon to begin preparations for the Africa Cup of Nations, which kicks off in Cameroon next month.